LINE-1 Retrotransposable Element DNA Accumulates in HIV-1-Infected Cells
نویسندگان
چکیده
منابع مشابه
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.
Type 1 long-interspersed nuclear elements (L1s) are autonomous retrotransposable elements that retain the potential for activity in the human genome but are suppressed by host factors. Retrotransposition of L1s into chromosomal DNA can lead to genomic instability, whereas reverse transcription of L1 in the cytosol has the potential to activate innate immune sensors. We hypothesized that HIV-1 i...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.02257-13